Breakthrough Infection Data In Israel: Troubling Trend or Mere Anomaly?

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Title : Breakthrough Infection Data In Israel: Troubling Trend or Mere Anomaly?
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Breakthrough Infection Data In Israel: Troubling Trend or Mere Anomaly?

 TrialSiteNews

Data out of Israel reveals some troubling trends involving this heavily vaccinated population. TrialSite delved into a recent data trove made available by the government there and has found that a majority of those now vaccinated actually, according to the numbers, face as much risk to succumb to delta-driven SARS-CoV-2 infection as unvaccinated individuals. Meaning, the vaccine appears to have a negligible effect on an individual at this point as to whether they in fact catch the current stain. Moreover, the data indicates that the current vaccines used (Moderna, Pfizer-BioNTech, AstraZeneca) may have a negligible effect on hospitalization and death if one does get infected with SARS-CoV-2. With a majority of vaccinations using the mRNA-based BTN162b2, what are the implications for this anomaly? Is this data statistically significant or it is merely an anomaly?

Vaccination Nation

First, we start with an introduction to Israel, a nation with just over 9 million people and one of the most vaccinated places on the planet. According to data from Reuters, Israel has administered 10.9 million doses, and given a majority of the population received the two-dose mRNA-based regiment, the estimated total vaccination rate against COVID-19 stands at 60.5% of the country’s total population. According to Fortune, that rate is 65%. These rates would imply that overall infections would wane, particularly in an advanced society driven by stringent public health policy.

Is the Pfizer Vaccine Losing Potency?

Recently in the Jerusalem Post, it was reported that the mRNA-based vaccine was less effective against the SARS-CoV-2 Delta variant than “health officials hoped,” reported Prime Minister Naftali Bennett last Friday. This online media reported that “855 people tested positive for coronavirus and more countries were listed as places of high infection.”  The Prime Minister declared, “We do not know exactly to what degree the vaccine helps, but it is significantly less.”

We don't know to what degree the vaccine helps but it is significantly less....

I just wanted to be clear on what Naftali Bennett said..

 

“We don’t know exactly to what extent the vaccine helps, but it is significantly less”

Yup, that's what he said. Someone added in the wording delta variant, but, it is not part of Bennett's quoted statement. Therefore it cannot be attributed to him. So clearly the correct statement is  We don’t know exactly to what extent the vaccine helps, but it is significantly less”

Less then what? Less then had been claimed? Less then the government told the people? 

Wish I knew?

More Concerning Data

TrialSite was able to secure the data sources from the Israeli government. Links include the data set as well as a public health data dashboard as well as a broader data resource link.  

An initial review of the data surprised the analysts. A summary follows a review of some examples. The first one reveals the week of June 27th to July 3rd in the age cohort 20-29 years old. According to the data in this cohort, those new COVID-19 cases involving individuals fully vaccinated totaled 79%. How about the percentage of this population that’s fully vaccinated? It turns out to be 78%, indicating that at least for this cohort, the vaccination rate doesn’t seem to impact the infection rate.

Clearly the majority becoming sick with Covid are allegedly vaccinated against Covid 

In another cohort, aged 30-39 from the week of June 27th to July 3rd, the new COVID-19 cases percentage involving people fully vaccinated came out at 80% while the percentage of the population in that age group fully vaccinated came in at 83%. 

In yet another example from the week of July 27th  ( I believe this is June 27th) to July 3rd in the 40-49 years old age group, new COVID-19 cases involving fully vaccinated people totaled 84%, and the percentage of the population in this age group that were fully vaccinated stood at 86%.

TrialSite notes that a number of questions needed to be asked involving sample size and whether this data is statistically significant or some anomaly.

But what about hospitalization numbers and deaths? Those numbers should be markedly down in the majority vaccination cohorts. According to the data set herein, the total number of hospitalizations is slightly higher in the vaccinated groups. Could this be linked to Antibody-Dependent Enhancement? This is something many vaccine experts wary of fast-tracked mRNA-based vaccines predicted could be a factor. Could this be a small difference now (with smaller numbers) yet lead to worsening numbers in forthcoming seasons?

 

Breakthrough Infection Problem?

In a recent study published in the Journal of Clinical Microbiology and Infection, Israel-based scientists and researchers link a growing number of bad SARS-CoV-2 cases, including death, to a minority of fully vaccinated individuals in this eastern Mediterranean nation. This study was led by corresponding authors Tal Brosh-Nissimov, Head of Infectious Diseases Unit, Samson Assuta Ashdod University, Israel; and Efrat Orenbuch-Harroch affiliated with Hadassah Hebrew University Medical Center, Jerusalem, Israel; and a team of other investigators. Of course, during Phase 3 clinical trials, the mRNA-based products exhibited compelling efficacy rates in protecting subjects from more severe forms of the pathogen. This efficacy was generally noted across all age groups, including the elderly and those with compromised immune systems and the like. Israel earned the status as one of the highest vaccinated nations worldwide. It was able to marshal its government and private sector resources across a population of just over 9 million. A great amount of collaboration across societal sectors helped, which hasn’t necessarily been the case in some other advanced nations. But now a disturbing set of data points emerge with breakthrough infections across the majority of vaccinated populations. There still isn’t sufficient data to determine the true nature of these observations. The tendency on one side is to declare that these products may not be working optimally while, on the other side, the data points are minimized with an emphasis on total overall trends. But there isn’t sufficient data to declare that these vaccines are an overwhelming success.

Where have I read this same news previously?

The Seychelles. Remember?

 

As per the latest data, more than 60 per cent of Seychelles’ population has been fully vaccinated and around 70 per cent has been administered at least one dose of the Covid-19 vaccine. The percentage of the fully vaccinated population is more than other vaccine giants like Israel and the United Kingdom.

In spite of these impressive vaccination figures, Seychelles this week reported the highest number of Covid-19 cases per capita, worse than a country like India which has not even 3 per cent of its population vaccinated

 Experts have been watching the situation in Seychelles closely for what it says about the effectiveness of vaccines

 

What else does this remind me of ?




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