Title : Is That Rush for a Third Covid Vaccine Booster Jab Necessary?
link : Is That Rush for a Third Covid Vaccine Booster Jab Necessary?
Is That Rush for a Third Covid Vaccine Booster Jab Necessary?
Stay tuned for an upcoming video that fits this news like a hand to a glove!
Thanks to a valued community member, TrialSite shares recent study results led by Spanish researchers. With important results published in Frontiers in Cellular and Infection Microbiology, TrialSite points to a growing chasm out there provoked by the mainstream media’s fear-mongering about waning immunity, risk of variants, and as TrialSite shares later today, the called-out need for booster shots. Importantly, a majority of the mainstream media-sensationalized headlines are premised on in vitro evidence regarding antibodies. This new study’s argument is intriguing. The first reports of waning immunity stem from accounts of recovered patients whose antibody titers revealed material decreases after 3 to 6 months. However, it’s well established that circulating antibodies rise rapidly soon after an acute infection, stabilize, and then start to decline. But humoral immunity persists in the form of memory B Cells that expeditiously produce massive volumes of antibodies in response to a reintroduction of the antigen. This exposure takes about 24 hours as opposed to the 8 to 12 days it takes after the first exposure.
The second time the headlines used these same scare tactics were when in vitro studies showed that antibodies had a lower neutralizing effect on variants versus the wild type. However, it’s not at all clear how much of a humoral response is required in order to repel a reinfection. The other factor is that humoral immunity (B Cells that produce antibodies) is only a portion of the adaptive immune response. The other main portion of the adaptive response is cellular immunity (Cytotoxic T cells). It’s been shown that cellular immunity is much more important for combating COVID-19 and avoiding the secondary inflammatory stage. In fact, it’s been demonstrated that an immune response dominated by TH2 (cellular) leads to poor outcomes and mortality.
In plain language the type of response generated by the vaccine leads to poor outcomes and mortality.
Humoral immunity is easy to measure because the antibodies are circulating in the blood. However, the more important cellular immunity is much more difficult to measure. Therefore, we haven’t had clear evidence around how much T Cell immunity might be waning and if T Cells would suffer a significant reduction in recognition to the variants’ epitopes. It’s been inferred that cellular immunity is more enduring than humoral when it comes to COVID-19 based on the real-world evidence of how natural immunity and vaccine-derived immunity are holding up well to the variants. This paper provides data to back up the real-world evidence that’s being observed.
Further Monetization by Pfizer?
This real-world evidence hasn’t prevented Pfizer from trying to cash in on another 3rd booster shot. Recently, they announced that they would seek FDA approval for a third dose of their original vaccine formula.
They based their case on a report out of Israel that the Delta variant is reducing the efficacy of the Pfizer vaccine to 64%. However, this is very questionable since little details were provided with this statement and it contradicts strong evidence to the contrary.
Recently, the UK published data that the Pfizer vaccine was still 88% effective at preventing symptomatic disease against the Delta variant. In addition, Pfizer also referenced the waning antibody titers after 6 months as justification for a 3rd shot. However, decreasing antibodies after 6 months is expected, and Pfizer fails to take into account the memory B Cells response or the T Cell response.
A Different Point of View
In this study, they combined an experimental and bioinformatics approach to address T cell reactivity to SARS-CoV-2 variants of concern (VoC). They directly assessed T Cell responses from individuals recovered from COVID-19 and those vaccinated with the mRNA vaccines for their capacity to recognize peptides derived from the ancestral reference sequence (wildtype) and the United Kingdom (UK) variant 501Y.V1 lineage B.1.1.7, the South Africa (SA) variant 501Y.V2 lineage B.1.351, the BR (Brazilian) variant 501Y.V3 lineage P.1, and the California (CA) variant CAL.20C lineages B.1.427–429.7.
This study was performed prior to the emergence of the Delta variant. However, being that the T Cells showed robust recognition for all prior variants, it’s highly likely that the same would be true for the Delta variant.
This study provides data to support the recent statement by the FDA and CDC to counter Pfizer’s claims and inform the public that a booster dose is not needed at this time.For instance, T Cell Epitopes are conserved at over 90% across all variants.
T cell immunity against other beta coronaviruses has proven long-lived. This study showed T cell immunity up to 11 years for SARS.
It’s likely that memory T Cell immunity will be similarly long-lived for SARS-CoV-2. The question has been if antigenic drift will cause the T cells to no longer recognize new variants. Thanks to this study, it’s clear that T cell immunity is continuing to recognize SARS-CoV-2 across all tested variants. Therefore, both recovered COVID-19 patients and vaccinated individuals can ignore the daily flood of sensationalized headlines for now.
Study Funding
This work was supported by grants: COVID-19 Research Call COV20/00181 and PI17-0147 from Institute of Health Carlos III from Spanish Ministry of Science and Innovation, co‐financed by European Regional Development Fund (ERDF, “A way to achieve Europe”).
Thus Article Is That Rush for a Third Covid Vaccine Booster Jab Necessary?
You are now reading the article Is That Rush for a Third Covid Vaccine Booster Jab Necessary? with the link address https://janggalnews.blogspot.com/2021/07/is-that-rush-for-third-covid-vaccine.html
0 Response to "Is That Rush for a Third Covid Vaccine Booster Jab Necessary?"
Post a Comment